Early Onset AMD, Wet Type.

by Bob
(USA)

Hello,

I am a 46 y.o. physician, in otherwise excellent health. I have blue eyes, and I am of Northern European descent. My father and paternal Grandmother have/had AMD. They are of German ancestry.

About 10 years ago, I noticed some blurriness in my central vision, Rt eye, that resolved over the course of a few days.

I saw an ophthalmologist, and had a normal exam. In 2007, I saw another ophthalmologist for a routine visit. He noted some hyperpigmentation changes in both macula. My exam was otherwise normal.

I recently noticed some visual distortion in my right eye, although I am still correctable to 20/20. Text appears slightly washed out in my central vision. When I open and close my right eye rapidly, facing a white wall or blank monitor, I see a central grey area when first opening my eye, that rapidly fades away.

This area corresponds in size and shape to the central vision distortion. Text also appears to dip about 1-2 mm centrally.

My physical/eye exam was said to be similar to 2007. I was referred to a retina specialist. He also noted drusen bilaterally. I had an optical coherence tomography (OCT) that showed some macular atrophy and abnormal fluid on the Rt.

Although not technically AMD, because of my age, that is basically what I have. I had my first intravitreal treatment on Thursday.

Mike, I am not an ophthalmologist, but I don't think Drusen are reversible. I would humbly suggest that you, if you have not done so already, establish a relationship with a retinal specialist, and inquire as the need for a baseline OCT, to better evaluate any future changes. While this may not be relevant for current care regimens, it may be of value for future treatment decisions, as new therapies continue to come on line.

In short, I think I have had my disease/maculopathy for at least 10 years. I still have 20/20 vision, and treatments continue to improve.

Anyone afflicted is fortunate, in the sense that the disease is so common. A tremendous amount of effort and resources are being directed at the problem. I hope this helped someone.

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Early Onset AMD, Wet Type.

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Sep 11, 2010
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Your Macular Drusen
by: R. Wong

Dear Bob,

Best of luck to you. Though you are not a retina specialist, your advice to Mike is...perfect.

If I can help in any way, please feel free to reach out.

Randy

Dec 18, 2009
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Thank You Dr. Wong
by: Bob

Thank you, very much, for your comments, Dr. Wong.

I agree with your "waste basket" characterization.

I think the group of disorders currently characterized as AMD are all disorders resulting in choroidal neovascularization, of unknown etiology, and therefore, idiopathic.

It's like "renal failure."

Over the course of time, we will undoubtedly learn that some are the result of disorders resulting in a predisposition to oxidative stress, some are impairment of coping with oxidative stress, and some have an entirely different mechanism.

If you can post again, do you have any recommendations as to facilities conducting research, current research information, and charitable foundations? Thanks. You did help. Bob

Dec 14, 2009
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Macular Degeneration Waste Basket
by: Randall Wong, M.D.

Macular degeneration is probably a large "waste basket" term for many diseases that look, and behave, similarly.

While you (Mike?) do not have typical macular degeneration, you may have "idiopathic" choroidal neovascularization (presuming why you had the intravitreal injection). The treatment would be the same with or without the AMD diagnosis.

Drusen, are not necessarily reversible, but are known to regress; that is, they may disappear.

Drusen are not associated with a particular stage of the disease, but can be risk factors for the development of choroidal neovascularization.

Hope this was helpful.

Randall V. Wong, M.D.
Retina Specialist
www.RetinaEyeDoctor.com

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